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. 2021 Jul 27;2021:6366254. doi: 10.1155/2021/6366254

Figure 5.

Figure 5

miR-146a affects NOX4-P38 signalling. (a) Protein level of NOX2, NOX4, phosphorylated- (P-) P38, and total- (T-) P38 in heart tissue in mice with miR-146a mimic treatment (n = 6). (b) Protein level of NOX4, P-P38, and T-P38 in NRCMs transfected with the miR-146a mimic (n = 6). (c) mRNA level of NOX2 and NOX4 in NRCMs transfected with the miR-146a mimic (n = 6). (d) Luciferase assay in NRCMs transfected with the miR-146a mimic and miR-146a inhibitor (n = 6). Cell experiments were repeated for 3 times. ∗P < 0.05vs. vehicle-sham/CON; #P < 0.05vs. vehicle-I/R or vehicle-H/R. Two-way analysis of variance was used in (a)–(c). Unpaired Student's t-test was used in (d).