Table 3.

Distribution of (pro)renin receptor expression in the brain.

	Case 1	Case 2	Case 3
Brain stem
Medulla
Nucleus tractus solitarii	+	+	+
Dorsal nucleus of vagus	+	+	+
Hypoglossal nucleus	+	+	+
Inferior olivary nucleus	+	+	+
Midbrain
Thalamus	+	+	+
Lateral nucleus	+	+	+
Medial nucleus	+	+	+
Hypothalamus
Paraventricular nucleus	+	+	+
Supraoptic nucleus	N/A	+	+
Mammillary body	+	+	+
Cerebrum
Grey matter	+	+	+
White matter	+	N/A	N/A
Hippocampus
Stratum radiatum	±	+	+
Pyramidal cell layer	+	+	+
Stratum lacunosum	±	+	+
Cerebellum
Molecular layer	±	±	±
Purkinje cell layer	+	+	+
Granular layer	±	±	±
Pituitary
Anterior lobe	+	+	+
Posterior lobe	−	−	+

The immunostaining intensity in the cytoplasm was evaluated on a scale of − (no staining), ± (borderline staining), and + (positive staining). N/A, not available.