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. 2021 Jul 21;596(7870):126–132. doi: 10.1038/s41586-021-03752-4

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© The Author(s) 2021, corrected publication 2021

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Extended Data Fig. 9 — a, b, Barplots summarize the total number of unique tumour-infiltrating clonotypes (a) and cells (b), stratified by antigen specificity and method of detection (MANAFEST or based on the TRM gene signature and cloning/peptide screen). Different colours represent the patient identity. c, Visualization of clonotypes included in the MANA-specific analysis. The individual UMAP projections of clonotypes that were validated (left) and were not validated (right) by TCR cloning are shown. Of the cells that corresponded to a MANAFEST-identified, MANA-specific clonotype that was detected in the single-cell data, >94% were validated by the jurkat/luciferase TCR cloning system.