Extended Data Fig. 3. Peripheral dynamics and cross-compartment representation of antigen-specific T cells.

Bulk TCRseq was performed on pre- and post-treatment tissue (left panels) and peripheral blood (right panels) for each patient in whom antigen-specific TCRs were identified by ViraFEST/MANAFEST (as shown in Extended Data Fig. 2 and Supplementary Data 5). Data are shown as the frequency of each influenza-, CEF-, and MANA-specific TCR clonotype among all TCRs detected by bulk TCR sequencing of the indicated tissue or peripheral blood time point. Antigen-specific clonotypes were not detected by bulk TCRseq of any available tissue/peripheral blood time point in patient NY016-025. TDLN, tumour draining lymph node; DLN, draining lymph node.