Table 1.

Estrogen-related associations of endometrial cancer, endometrioid and clear cell ovarian cancers, breast cancer and thyroid cancer

	Endometrial cancer	Endometrioid ovarian cancer	Clear cell ovarian cancer	Breast cancer	Thyroid Cancer
Unopposed exogenous estrogen	↑ ↑ (17)	↑ (33)	0 or ↓ (33,39)	↑? (74,75)	0? (58,63-66)
Age at menopause	↑ (22)	↑ (34)	↑ (34)	↑ (70)	? (48,51-53)
Age at menarche	↓ (4,23)	0 (34)	↓ (34)	↓ (70)	↑? (48,50)
Parity	↓ (4,21)	↓ (34)	↓ (34)	↓ (72,73)	↑ (48,49)
Post-menopausal BMI	↑ (4,18,19)	↑(34-36)	0? (34-36)	↑ (71)	↑? (56-62)

↑↑ greatly increased risk; ↑ increased risk; 0 no association; ↓ decreased risk; ? unclear; 0? Suggestion of no association; ↑? Suggestion of increased risk