Extended Data Fig. 10. Cerebellar cell type enrichment in Joubert syndrome and Alzheimer’s disease.

Heatmaps of mean expression per fetal cerebellar cell type for genes associated with Joubert syndrome (a) or Alzheimer’s disease (b). Color scheme is based on Z-score distribution. In the heatmaps, each row represents one gene and each column represents a single cell type. Horizontal white lines indicate branch divisions in the clustering dendrograms (not shown). The full list of genes is provided in Supplementary Table 11. Enrichment P values (-Log10 P value) for each cell type are shown in the bottom bar plots. Significance determined by one-sample Z-test, two-tailed P value. The dashed line is the Bonferroni significance threshold (P<0.05); no gene enrichment was detected among the 21 cerebellar cell types.