Figure 2.
Results of the GSEA analysis. Considering the Hallmark pathways (well-defined biologic states), the top three pathways significantly upregulated in tumors with a high SUVmax were Inflammatory Response (A), TNF-α signaling via NF-κΒ (B), and IL-6 JAK STAT3 signaling (C). All remained significant accounting for false discovery rate (FDR), and the Inflammatory Response and NF-κΒ gene sets also had a family-wise error rate (FWER) < 0.05, though JAK/STAT3 signaling did not. These gene sets shared a number of genes, many of which help regulate immune cells (bolded), particularly myeloid-derived cells. The genes displayed were shared by at least 2 of the gene sets.