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. 2021 Jun 21;34(5):1446–1454. doi: 10.1007/s13577-021-00568-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Quantitative variation of GC-CTM following treatment and its relevance to prognosis. A Percentages of patients with pre-therapeutic, acquired intra-therapeutic CTM⁺ and CTM⁻. B Quantitative comparison of CTM number before treatment and post-PD. The histograms and heatmaps, respectively, indicate the total and average number of CTM before treatment and post-PD. C A heatmap shows quantitative variations in CTM before treatment and post-PD in individual PD patients. Increased or decreased CTM numbers are indicated by red or blue color in the heatmap, the white color represents no detectable CTM. D, E Kaplan–Meier curves of PFS (D) and OS (E) in relation to pre-therapeutically CTM enumeration