Table 3.

Comparison between MDB-based relative volumes between consecutive CS-factors (1 vs. 4, 4 vs. 8, etc.) across all subjects: p-values of paired t tests, Cohen’s d as measure of effect size

CS-factors	1 vs. 4		4 vs. 8		8 vs. 12		12 vs. 16		16 vs. 20		20 vs. 32
	p	d	p	d	p	d	p	d	p	d	p	d
BP	0.010	0.53	0.591	–	< 0.001*	1.28	< 0.001*	1.38	0.001	0.75	< 0.001*	2.33
GM	< 0.001*	− 1.07	< 0.001*	− 2.99	< 0.001*	− 1.14	< 0.001*	− 2.54	< 0.001*	− 2.18	< 0.001*	− 3.88
WM	< 0.001*	1.03	< 0.001*	1.75	< 0.001*	1.76	< 0.001*	2.12	< 0.001*	1.45	< 0.001*	4.03
CSF	< 0.001*	1.51	< 0.001*	3.14	< 0.001*	1.82	< 0.001*	2.56	< 0.001*	1.77	< 0.001*	3.61

CS compressed SENSE, MDB md.brain segmentation and volumetry tool, BP brain parenchyma, WM white matter, GM gray matter, CSF cerebrospinal fluid

*Marks significant difference to volume at consecutive CS-factor (p < 0.05)