Table 5.

Comparison between FS-based relative volumes between consecutive CS-factors (CS = 1 vs. CS = 4, CS = 4 vs. CS = 8, etc.) across all subjects: p-values of paired t tests, Cohen’s d as a measure of effect size

CS-factors	1 vs. 4		4 vs. 8		8 vs. 12		12 vs. 16		16 vs. 20		20 vs. 32
	p	d	p	d	p	d	p	d	p	d	p	d
BP	0.805	–	0.0031*	0.63	< 0.001*	2.46	0.0047*	0.60	0.0016*	0.68	< 0.001*	1.85
GM	0.159	–	0.0148*	0.50	< 0.001*	0.74	0.0043*	0.60	0.0129*	0.51	< 0.001*	2.41
WM	0.780	–	0.0279*	0.45	< 0.001*	2.14	< 0.001*	0.73	0.0013*	0.69	< 0.001*	1.41
CSF	0.013*	0.51	< 0.001*	− 0.54	0.001*	− 0.71	< 0.001*	− 0.90	0.0151*	− 0.50	< 0.001*	− 1.19

CS compressed SENSE, FS FreeSurfer segmentation and volumetry tool, BP brain parenchyma, WM white matter, GM gray matter, CSF cerebrospinal fluid

*Marks significant difference to volume at subsequent CS-factor (p < 0.05)