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The apparent binding affinity between sPD-1 wild-type Fc, sPD-1V1 Fc, and sPD-1V2 Fc in co-complex with human PD-L1 and PD-L2.
| Analyte | Ligand | ka (1/ms) | kd (1/second) | Kd (mol/L) |
|---|---|---|---|---|
| Human PD-L1 | sPD-1 WT | N/A | N/A | 2.743E-6 |
| sPD-1V1 | 2.038E+6 | 6.941E-4 | 3.406E-10 | |
| sPD-1V2 | 2.139E+6 | 7.500E-4 | 3.420E-10 | |
| Human PD-L2 | sPD-1 WT | 1.811E+5 | 0.1029 | 5.471E-7 |
| sPD-1V1 | 4.366E+6 | 0.01288 | 2.949E-9 | |
| sPD-1V2 | 4.479E+6 | 0.01524 | 3.402E-9 |
