Extended Data Fig. 3. Decision criterion but not sensitivity, is impacted by unilateral SC inactivation during one-interval, two-choice perceptual decision-making.

(Associated with Fig. 2 main text) a Sensitivity, as measured by d’ is plotted against coherence for all experiments from both monkeys pre-muscimol (black circles and lines), post-muscimol (orange circles and lines) and 24 hour recovery (green circles and lines). Dashed lines show data from monkey B and solid lines show data from monkey S. Note that for monkey S, there is an additional 50% coherence condition (Methods). Qualitatively, monkey B showed a higher sensitivity for the same Glass pattern coherences than monkey S. b d’ collapsed over coherence and plotted for pre-muscimol (grey circles), post-muscimol (orange circles) and recovery (green circles) for all experiments from both monkeys. Dashed lines show data from monkey B (n=11 injections) and solid lines show data from monkey S (n=12 injections). The horizontal lines indicate the mean d’ across sessions. On average there were no significant changes in d’ with muscimol in either monkey (monkey S, t(11) = −1.54, p = 0.152, 95% CI = [−0.23, 0.07]; monkey B, t(10) = −1.51, p = 0.161, 95% CI = [−0.21, 0.07]). c–d Same as in a and b for the saline injections. Because we only had two saline injections in monkey B, we collapsed the data across monkeys (n=6 injections) for statistical analysis, but the data are shown separated by monkey. We found no significant differences in d’ with saline (t(5) = 1.20, p = 0.283, 95% CI = [−0.1, 0.19]). Note that there are no d’ or criterion (c) values for monkey B for the 24% and 36% coherences due to a lack of errors for the awayIF post-muscimol 24% and 36% coherence trials. e Criterion (c) plotted against coherence for pre-muscimol (black), post-muscimol (orange), and recovery (green) for all experiments from both monkeys. Dashed lines are from monkey B and solid lines are from monkey S. This plot is shown for symmetry with the d’ plot although criterion changes across coherences are not particularly meaningful as monkeys are not expected to change their criterion across coherences as the coherences were randomized from trial to trial and there was no way for the monkeys to know which coherence was impending. f Criterion collapsed over coherence plotted for pre-muscimol, post-muscimol and recovery for all experiments (n=12 injections for monkey S, n=11 injections for monkey B). For both monkeys, c changed significantly with muscimol (monkey S, t(11) = −9.34, p = 1.46 × 10 ⁻⁶, 95% CI = [−0.7, −0.38], monkey B, t(10) = −7.48, p = 2.10 × 10 ⁻⁵, 95% CI = [−0.75, −0.33]). g–h Same as in e-f for the saline experiments from both monkeys (n=6 injections). We found no significant differences in c with saline injections (w(5) = 18, p = 0.156). Consistent with the psychometric function results shown in Fig. 2, unilateral inactivation of SC with muscimol produced changes in decision bias and not perceptual sensitivity.