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. 2021 Aug 4;11:15782. doi: 10.1038/s41598-021-95245-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IL-15 stimulates KIR⁺ lymphocyte expansion. (A) Representative density plots illustrating KIR2DL1/2/3/2DS1/2 expression on CD56⁻ T cell subsets targeted using CD3 and CD56 combination at day 0 by flow cytometry (B) and day 10 after PBMC culture with IL-2 at 50 U/ml alone or in combination with IL-12 (10 and 20 ng/ml) or IL-15 (5 and 10 ng/ml). The cell frequency is indicated on all density plots. (C) Floating bars (min to max) compiling results of different experiments realized from 3 healthy blood donors. *Indicates p < 0.05, ANOVA. (D) Representative histograms of KIR⁻ and KIR⁺ T cell proliferation by the method of CFSE that allows the identification of dividing cells stimulated for 6 days with 10 ng/ml IL-15. Generation’s gates are indicated (DO to D5).