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. 2021 Aug 4;11:15782. doi: 10.1038/s41598-021-95245-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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KIR2DL3 inhibits T lymphocyte apoptosis. (A) Density plots illustrating apoptotic HLA-A2-pp65 specific KIR2DL2/3⁺ T lymphocytes as annexin V⁺ 7AAD⁻ after 3 h incubation alone or in presence of pp65 (0.1 µg/ml) loaded allogeneic C1C1 (ChT, HiD) and C2C2 (JVM, BM9) EBV-B cell lines for one representative C1C2 individual (I16) performed twice and for 2 C1C2 individuals. Mean Fluorescent Intensity (MFI) of Annexin V⁺ cells is indicated on all density plots. (B) Histograms representing annexin V expression by HLA-A2-pp65 specific KIR2DL3⁺ T lymphocytes after 3 h incubation alone or in presence of pp65 (0 and 0.1 µg/ml) loaded allogeneic C1C1 (ChT, HiD) and C2C2 (JVM, BM9) EBV-B cell lines for one C2C2 individual (I19). Mean Fluorescent Intensity (MFI) of Annexin V⁺ cells is indicated for all conditions. (C) Density plots illustrating HLA-A2-pp65 specific KIR2DL3⁺ T cell degranulation in the presence of pp65 (0 and 0.1 µg/ml) loaded allogeneic C1C1 (ChT, HiD) and C2C2 (JVM, BM9) EBV-B cell lines for one C2C2 individual (I19).