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. 2021 Aug 4;11:15842. doi: 10.1038/s41598-021-94542-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Temporal trends in HIV-1 subtypes proportions in Brazil. Pearson correlation plots between subtype proportion and sampling year (2008–2017) are shown for HIV-1B, C and F1 per Brazilian region. Only statistically significant (p < 0.05) correlations are presented. The analysis was performed separately for women (left) and men (right). For the temporal trend of HIV-1 recombinant strains, see Supplementary Figure 4.