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. 2021 Aug 4;12:4697. doi: 10.1038/s41467-021-24993-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Organization of control Caco-2 3D structures displaying apical-basal polarity and epithelial organization, and CD13-depleted cells showing inverted apical-basal polarity and impaired lumen formation. b CD13 associates with apical complex containing Par6, aPKC, Pals1, and Crb3. c Proposed events by which CD13 functions to establish the orientation of apical-basal polarity. CD13 associates with apical proteins (1) and is required for their loading to Rab11-mediated endosomes (2). In parallel, CD13 establishes Rab35 at the AMIS (3) necessary to capture vesicles containing apical determinants for apical membrane initiation (4). See discussion for a further explanation.