Table 5.
Left ventricular and aortic remodeling in humans according to medical treatment.
| MFS without drugs N = 15 |
MFS with drugs N = 30 |
P | |
|---|---|---|---|
| Age [yo] | 27 ± 8 | 30 ± 8 | 0.33 |
| Weight [kg] | 76 ± 14 | 81 ± 15 | 0.26 |
| High [cm] | 183 ± 9 | 189 ± 12 | 0.08 |
| BSA [m2] | 1.97 ± 0.2 | 2.08 ± 0.2 | 0.12 |
| Aortic root ind. [mm/m2] | 19.5 ± 3 | 21.3 ± 3 | 0.04 |
| Asc Ao ind. [mm/m2] | 16 ± 3 | 16 ± 2 | 0.95 |
| LVEDD ind. [mm/m2] | 27 ± 5 | 25 ± 3 | 0.13 |
| LVESD ind. [mm/m2] | 17 ± 4 | 16 ± 2 | 0.18 |
| IVS ind. [mm/m2] | 4.6 ± 1 | 5 ± 0,7 | 0.09 |
| PW ind. [mm/m2] | 3.9 ± 0.4 | 3.9 ± 0.4 | 0.56 |
| LV mass ind. [g/m2] | 81 ± 20 | 83 ± 18 | 0.63 |
| LVEF[%] | 62 ± 5 | 61 ± 6 | 0.66 |
| SBP [mmHg] | 120 ± 12 | 118 ± 11 | 0.49 |
| DBP [mmHg] | 74 ± 9 | 72 ± 9 | 0.52 |
| PST + | 8 (53%) | 17 (57%) | 0.832 |
BSA body surface area, AoR aortic root diameter, Asc Ao ascending aorta diameter, LVEDD left ventricular end-diastolic diameter, LVESD left ventricular end-systolic diameter, LVEF left ventricular ejection fraction, IVS interventricular septum thickness, PW posterior wall thickness, SBP systolic blood pressure, DBP diastolic blood pressure, PST: postsystolic thickening, ind.: indexed by BSA. Data is presented as mean ± SD for continuous variables.
Independent two-sample t-test for normally distributed continuous variables and the Mann–Whitney U test for non-parametric distribution were used. Categorical variable (PST) is presented as percentage (%) and compared using χ2 test. P<0.05, in bold, denote statistical significance.