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. 2021 Aug 4;11:15799. doi: 10.1038/s41598-021-95086-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo efficacy analysis of dose 10¹³ and dose 10¹⁴ in vaccinated BALB/c mice. (A) Representation of in vivo experimental setup of the BALB/c mice vaccinated with dose 10¹³ or dose 10¹⁴ of OZG-38.61.3. (B) The bar graph showing the presence (absorbance) of SARS-CoV-2 specific IgG in the mice sera diluted with either 1:128 or 1:256 detected using ELISA. (C) The bar graph showing the neutralization frequency of the mice sera diluted to 1:128 or 1:256 that were pre-incubated with a 100 × TCID50 dose of infective SARS-CoV-2. The analysis was performed with MTT analysis at 96 h. (D) The bar graph showing activation frequency (IFNγ positive spot count) of spleen T cells that were incubated with SARS-CoV-2 specific peptides. (E) The bar graph showing the proportion of the activated T cells after the stimulation. The activation was determined with the upregulation of the CD25 surface marker. (F) The bar graph showing cytokine proportions of spleen T cells that were incubated with SARS-CoV-2 specific peptides. (G) Histopathologic analysis of the lung, kidney, and liver tissues of BALB/c mice groups. H&E stain X400.