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. 2021 Aug 4;12:4702. doi: 10.1038/s41467-021-25055-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a The distribution of distances between indels that together form a scar. In the 69 scars that resulted from exactly two indels, the majority had a distance of <10 nucleotides between the two indels. b Gene segments are shown for indels in scars that had exactly two indels. Each gene is divided in ten equal segments to show the locations of scar indels in the genes. Each indel is shown as a filled cyan circle and the two scar indels are connected by a cyan line if they occur in different gene segments. The absence of a cyan line indicates that both indels occurred in the same gene segment. 86% of these 69 frameshift scars had both the frame-shifting and frame-restoring indel in the same or neighboring gene segment. c and d The gene-fraction below threshold complexity scores is shown for scarred genes (black filled circles) and the non-essential and non-PE-PPE genes that do not have scars (non-scarred NENP, faded green circles), with c showing data for LC and d showing data for H. The threshold scores (H = 0.932, LC=0.551) are the lowest H/LC scores in the indel pockets in Fig. 2a.