TABLE 3.
Odds ratios (95% Cl) for main effect relationships between baseline characteristics of co‐morbid history and atrial fibrillation status group and five clinical outcomes
| Baseline characteristic | Heart failure | Stroke | Myocardial infarction | Major bleeding | Cognitive impairment | |
|---|---|---|---|---|---|---|
| AF status | AF vs Non‐AF | 6.02 (5.72‐6.33) | 2.17 (2.05‐2.30) | 2.68 (2.51‐2.87) | 1.36 (1.28‐1.44) | |
| Heart failure | (1 vs 0) | 19.08 (18‐32‐19.88) | 1.19 (1.12‐1.26) | |||
| Hypertension | (1 vs 0) | 2.16 (2.07‐2.25) | 1.57 (1.51‐1.63) | 1.68 (1.60‐1.76) | 1.18 (1.15‐1.20) | 1.12 (1.06‐1.17) |
| Diabetes mellit us | (1 vs 0) | 1.68 (1.62‐1.74) | 1.34 (1.29‐1.39) | 1.30 (1.24‐1.36) | 1.10 (1.07‐1.14) | 1.17 (1.11‐1.23) |
| Ischemic stroke | (1 vs 0) | 10.43 (9.92‐10.97) | 1.27 (1.19‐1.36) | 1.24 (1.14‐1.35) | ||
| Transient ischemic attack | (1 vs 0) | 4.22 (3.99‐4.48) | 1.15 (1.07‐1.24) | |||
| Thrombo‐embol c events | (1 vs 0) | 5.45 (4.82‐6. 6) | 1.17 (1.00‐1.36) | |||
| Myocardial infarction | (1 vs 0) | 1.26 (1.19‐1.35) | 11.99 (11.42‐12.59) | |||
| Peripheral artery disease | (1 vs 0) | 1.21 (1.15‐1.27) | 1.49 (1.42‐1.57) | 1.16 (1.11‐1.21) | 1.14 (1.07‐1.22) | |
| Valvular disease | (1 vs 0) | 1.50 (1.44‐1.57) | 1.14 (1.09‐1.19) | 1.13 (1.09‐1.18) | ||
| Coronary artery disease | (1 vs 0) | 1.65 (1.59‐1.72) | 1.16 (1.11‐1.20) | 4.26 (4.07‐4.45) | 1.08 (1.04‐1.12) | |
| Chronic sleep apnea | (1 vs 0) | 1.35 (1.25‐1.47) | 1.10 (1.01‐1.21) | 1.17 (1.10‐1.24) | 1.28 (1.13‐1.44) | |
| Chronic kidney disease | (1 vs 0) | 1.55 (1.48‐1.62) | 1.09 (1.0 4‐1.50) | 1.13 (1.08‐1.17) | ||
| Chronic pulomonary obstructive disease/bronchiectasis | (1 vs 0) | 1.66 (1.60‐1.72) | 1.20 (1.15‐1.25) | 1.25 (1.20‐1.31) | 1.23 (1.19‐1.27) | 1.07 (1.01‐1.12) |
| Major bleeding | (1 vs 0) | 1.25 (1.18‐1.31) | 4.22 (4.10‐4.33) | 1.19 (1.11‐1.27) | ||
| Cognitive impairment | (1 vs 0) | 1.14 (1.06‐1.23) | 17.38 (16.48‐18.33) | |||
| Liver disease | (1 vs 0) | 1.11 (1.06‐1.17) | 1.09 (1.0 4‐1.15) | 1.35 (1.31‐1.39) | 1.13 (1.06‐1.21) | |
| Anemia | (1 vs 0) | 1.19 (1.14‐1.23) | 1.10 (1.06‐1.15) | 1.35 (1.31‐1.39) | 1.18 (1.12‐1.23) | |
| lipid disorders | (1 vs 0) | 1.22 (1.18‐1.26) | 1.24 (1.18‐1.30) | 1.16 (1.13‐1.19) | 1.10 (1.05‐1.16) | |
| Depression | (1 vs 0) | 1.23 (1.17‐1.28) | 1.31 (1.25‐1.37) | 1.18 (1.12‐1.25) | 1.25 (1.22‐1.29) | 2.14 (2.03‐2.25) |
| Spondylosis/interverbral discs | (1 vs 0) | 1.10 (1.07‐1.14) | 1.21 (1.18‐1.25) | 1.10 (1.06‐1.14) | 1.33 (1.30‐1.36) | 1.26 (1.21‐1.31) |
| Osteoarthritis | (1 vs 0) | 1.14 (1.10‐1.18) | 1.08 (1.05‐1.12) | 1.06 (1.01‐1.10) | 1.15 (1.12‐1.18) | 1.11 (1.06‐1.16) |
| Gender | Female vs male | 0.91 (0.88‐0.94) | 0.96 (0.93‐0.99) | 0.69 (0.66‐0.71) | 1.04 (1.00‐1.09) | |
| Age group | > 75 years vs 18‐44 years | 7.45 (6.97‐7.97) | 8.67 (8.13‐9.25) | 5.01 (4.63‐5.42) | 1.86 (1.79‐1.93) | 40.80 (36.85‐45.16) |
| 65‐74 years vs 18‐44 years ears | 5.08 (4.76‐5.43) | 6.32 (5.94‐6.72) | 4.42 (4.10‐4.77) | 1.57 (1.52‐1.63) | 17.84 (16.11‐19.75) | |
| 55‐64 years vs 18‐44 years | 3.23 (3.03‐3.45) | 3.39 (3.18‐3.60) | 3.46 (3.21‐3.73) | 1.26 (1.23‐1.30) | 5.10 (4.58‐5.68) | |
| 45‐54 years vs 18‐44 years | 2.14 (2.00‐2.29) | 2.31 (2.17‐2.45) | 2.69 (2.51‐2.89) | 1.17 (1.13‐1.20) | 2.22 (1.98‐2.48) | |
| C‐index | 0.917 | 0.860 | 0.890 | 0.696 | 0.909 | |
1‐Presence of condition or female for gender.
0‐Absence of condition or male for gender.
Results shown for main effect model.