| Dose |
Bowel movements |
Author |
| Naloxegol 25 mg/d vs usual care |
Did not assess spontaneous bowel movements |
Webster et al. [31] |
| Naloxegol 25 mg, 12.5 mg vs placebo |
Median time to bowel movement response 7.6 hours for naloxegol 25 mg 19.2 hours for 12.5 mg 41.1 hours for placebo |
Tack et al. [32] |
| Naloxegol 5 mg, 25 mg, 50 mg once daily or placebo |
At week 1, the median change from baseline in spontaneous bowel movements per week: In the 5-mg dose group; no statistical difference versus placebo (1.5 vs 1.2) In the 25 mg dose group; a statistically significantly greater change from baseline versus the placebo (2.9 vs 1.0). In the 50-mg dose group, a statistically significantly greater change from baseline versus the placebo (3.3 vs 0.5). At weeks 2-4, the median change from baseline in spontaneous bowel movements per week: For the 50 mg dose group: was statistically significantly greater vs placebo at all time points during weeks 2, 3, and 4. For 25 mg dose group: was statistically significantly greater vs placebo at all time points except week 2 |
Webster et al. [33] |
| Naloxegol 25 mg, 12.5 mg vs placebo |
Did not assess spontaneous bowel movements |
Coyne et al. [34] |
