Fig. 3.

Baseline-adjusted microbiota diversity (upper panel a) and circulating biomarkers (lower panel b). The bars within each sector show baseline levels vs levels after three months for all groups. The notation above the thin brackets indicates p-value for within-group change. The notation above the thick brackets indicates the p-value for difference between baseline-adjusted mean after three months for investigational drugs vs control. The p-value above the thin brackets indicate within-group differences. CRP = C-reactive protein. NT-proBNP = N-terminal pro-B-type natriuretic peptide. S.boulardii = Saccharomyces boulardii. SoC = Standard of care. TMAO = Trimethylamine N-oxide.