. 2021 Jul 22;12:690539. doi: 10.3389/fpsyg.2021.690539

TABLE 5.

Anxiety, depression and health-related quality of life at study time points (Per protocol analysis, n = 15).

	Within-group effect								Between-group effect (time × group)
	T0		T1^a		ES	T2^a		ES	T1-T0^b		T2-T0^b		F	p	ES
	Mean	SD	Mean	SD	d	Mean	SD	d	Mean	SE	Mean	SE			Partial η²
BAI													3.25	0.07	0.35
I-BMS	8.25	4.83	2.50*	1.69	–1.59	3.00*	2.27	–1.39	−5.75**	1.52	−5.25*	1.55
Control	6.29	5.02	5.43	5.80	–0.16	4.00*	5.39	–0.44	–0.86	1.63	–2.29	1.66
BDI													9.01	0.00	0.60
I-BMS	13.63	8.86	3.25**	3.41	–1.56	3.50*	2.78	–1.55	−10.38***	1.86	−10.13**	2.37
Control	11.57	7.53	10.00	6.53	–0.22	8.43*	6.93	–0.43	–1.57	1.99	–3.14	2.53
Health Related Quality of Life (PCOSQ)
Total													13.42	0.00	0.69
I-BMS	151.50	20.98	173.88**	17.19	1.17	178.87**	22.40	1.08	22.38**	5.20	27.38**	7.56
Control	135.43	31.12	117.86**	29.66	–0.58	139.14	35.69	0.11	−17.57*	5.56	3.71	8.08
Hirsutism													3.23	0.08	0.35
I-BMS	32.25	2.87	33.75	1.75	0.63	34.38	1.77	0.89	1.50	1.72	2.13	1.85
Control	25.29	7.99	20.57	9.59	–0.54	23.71	9.62	–0.18	–4.71	1.84	–1.57	1.97
Acne													3.80	0.05	0.39
I-BMS	25.38	3.16	27.00	1.85	0.63	27.25	1.49	0.76	1.63	1.34	1.88	1.43
Control	18.00	8.62	15.00	6.27	–0.40	17.86	7.34	–0.02	–3.00	1.44	–0.14	1.53
Obese													2.38	0.13	0.28
I-BMS	25.38	10.99	30.00	7.27	0.50	29.62*	8.26	0.44	4.63	1.90	4.25*	1.46
Control	22.00	6.11	20.71	6.02	–0.21	24.43	8.22	0.34	–1.29	2.03	2.43	1.56
Infertile													1.23	0.33	0.17
I-BMS	9.88	5.19	11.75	3.41	0.43	14.12	4.91	0.84	1.88	1.37	4.25	1.64
Control	12.00	5.48	11.00	5.00	–0.19	12.71	4.79	0.14	–1.00	1.46	0.71	1.76
Menstrual													0.96	0.41	0.14
I-BMS	25.00	4.87	28.38	6.99	0.56	29.13	4.55	0.88	3.38	2.51	4.13	2.03
Control	22.43	4.58	20.86	4.18	–0.36	23.29	2.56	0.23	–1.57	2.68	0.86	2.17
Emotion													6.59	0.01	0.52
I-BMS	33.63	12.01	43.00*	5.04	1.02	44.37*	8.82	1.02	9.38*	2.91	10.75*	3.40
Control	35.71	12.01	29.71	9.60	–0.55	37.14	13.03	0.11	–6.00	3.11	1.43	3.63

BAI, Beck Anxiety Inventory; BDI, Beck Depression Inventory-II; PCOSQ, Polycystic Ovary Syndrome Questionnaire; SD, standard deviation; ES, effect size; SE, standard error. ^aWithin-group difference using paired t-test. ^bBetween-group difference using independent t-test. *p < 0.05; **p < 0.01; ***p < 0.001.