Skip to main content
. 2021 Jul 28;2(3):100701. doi: 10.1016/j.xpro.2021.100701

Figure 5.

Figure 5

Diurnal expression of circadian clock genes in mouse tissues subjected to time-restricted feeding (tRF)

(A–D) Diurnal expression of clock genes Nr1d1 and Arntl in female mouse liver (A), VAT (B), heart (C), and kidney (D) subjected to 36-day tRF.

(E–H) Diurnal expression of clock genes Nr1d1 and Arntl in male mouse liver (E), VAT (F), heart (G), and kidney (H) subjected to 7-day tRF.

Data were represented as mean ± sem (n = 4). Multiple t tests with Bonferroni correction; ns, p > 0.05, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001. Phase was calculated by MetaCycle (meta2d_phase). Phase shifts were represented by the absolute value of phase difference between DRF and NRF in a 12-h window, and calculated by CircaCompare, which provides a p-value for phase-shift. Figure reprinted with permission from Xin et al., 2021.