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. 2021 Jul 22;12:663793. doi: 10.3389/fneur.2021.663793

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Copyright © 2021 Lin, Elbezanti, Schirling, Ahmed, Van Duyne, Cocklin and Klase.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of alprazolam and SAHA on Gag specific CTL response. PBMCs from 5 HIV-1 positive individuals suppressed on therapy were treated with vehicle control, 500 nM SAHA, 100 nM alprazolam, SAHA plus alprazolam or 100nM Ro5-3335 overnight and then exposed to a set overlapping Gag peptides in the presence of Brefaldin A for 6 h. Cells were stained for live/dead marker, CD3, CD4, CD8 and cytokines of interest. The number of (A) IFNγ, (B) TNFα (C) IL-2 expressing CD8+ T-cells for each condition is shown normalized to untreated control. *P ≤ 0.05, ***P ≤ 0.001, ****P ≤ 0.0001, ns = not significant.