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. 2021 Jul 22;8:713170. doi: 10.3389/fcvm.2021.713170

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Copyright © 2021 Liu, Wu, Xu, Saaoud, Vasilopoulos, Shao, Zhang, Wang, Shen, Yang, Lu, Sun, Drummer, Liu, Li, Hu, Yu, Praticò, Sun, Jiang, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two hundred sixty organelle crosstalk regulators (OCRGs) in 16 groups were analyzed. There are 16 classification or function of these genes, including nine mitochondria (MT)-related gene populations: MT biogenesis (five genes), MT fusion (15 genes), MT fission (28 genes), MT fission and fusion (seven genes), mitophagy (28 genes), ER–MT contact site (13 genes), MT contact site (four genes), sarcoplasmic reticulum–MT contact site (nine genes), and MT protein translocation (seven genes); three endoplasmic reticulum (ER)-related populations except ER–MT contact site: ER–endosome contact site (seven genes), ER–Golgi interact genes (6), and ER–PM junctions (10 genes); endosome–Golgi trafficking (four genes); autophagosome–lysosome fusion (four genes); autophagosome–endosome/lysosome fusion (nine genes); vesicle-related (125 genes) coded proteins are enhanced by the Human Protein Atlas. Because some genes have more than one function, the final selection is 260 non-repetitive genes. The detailed gene list is in Table 1.