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. 2021 Jul 22;8:713170. doi: 10.3389/fcvm.2021.713170

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Copyright © 2021 Liu, Wu, Xu, Saaoud, Vasilopoulos, Shao, Zhang, Wang, Shen, Yang, Lu, Sun, Drummer, Liu, Li, Hu, Yu, Praticò, Sun, Jiang, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Donut chart shows the different classification/function ratios of upregulated and downregulated OCRGs in acute inflammations (AIs), metabolic diseases (MDs), autoimmune diseases (ADs), and organ failures (OFs). From the center to the outside of the donut chart, the circle represents the ratios of OCRGs in acute inflammations (AIs), organ failures (OFs), metabolic diseases (MD), autoimmune diseases (ADs), and all 260 OCRGs in turn. Groups of upregulated OCRGs in AIs (3) and OFs (7) are less than in MDs (12) and OFs (14) (left). In the 21 upregulated genes in AIs, vesicle-related genes account for 64%, and mitophagy and mitochondrial (MT) fission genes account for 14 and 23%, respectively. In the 26 upregulated genes in OFs, the top 3 high-number genes are vesicle- (50%), mitophagy- (12%), and MT fusion-related (12%) OCRGs. In the 34 upregulated genes in MDs, vesicle- (43%), MT fission- (11%), and mitophagy-related (11%) genes are the top 3 genes with high proportion. In the 59 upregulated genes of ADs, vesicle-related genes account for 41%, MT fission genes account for 13%, and mitophagy genes account for 11%. The downregulated OCRGs distributed in AIs, OFs, MDs, and ADs are 15, 15, nine, and 14 groups, respectively (right). In the 58 downregulated genes in AIs, the top 3 high-number genes are vesicle- (28%), MT fission- (14%), and mitophagy-related (13%) genes. In the 99 downregulated genes in OFs, the proportions of vesicle (56%), MT fission (12%), and ER–plasma membrane (PM) junctions (5%) genes are higher than those of others. In the 34 downregulated genes in MDs, the numbers of vesicle (45%), MT fission (13%), and endoplasmic reticulum (ER)–MT contact genes (13%) are higher. In ADs, vesicle (51%), MT fission (12%), and MT fusion genes (8%) are the top 3. These results show that different diseases have different expression patterns of OCRGs and that the classification proportion of upregulated and downregulated genes in the same type of diseases is different, which may explain the different functions of OCRGs in the occurrence and development of diseases. Abbreviations: ER, endoplasmic reticulum; GC, Golgi complex; MT, mitochondria; PM, ER–plasma membrane.