Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 22;8:713170. doi: 10.3389/fcvm.2021.713170

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Liu, Wu, Xu, Saaoud, Vasilopoulos, Shao, Zhang, Wang, Shen, Yang, Lu, Sun, Drummer, Liu, Li, Hu, Yu, Praticò, Sun, Jiang, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

More OCRGs were significantly expressed in influenza virus- and icMERS-inoculated cells. (A) In H1N1-infected human microvascular endothelial cells, H7N9-, H7N7-, H5N1-, and H3N2-infected Calu-3 cells and H9N2-infected human umbilical vein endothelial cells, MX1 and SYNPO2 were the common upregulated OCRGs shared by these six types of flu virus-treated cells; no common downregulated genes were shared by these six flu virus-treated cells. When the overlapped 47 genes were removed, 40 genes are upregulated and 143 genes are downregulated in these five influenza virus-infected cells. (B) In time course, MERS coronavirus-inoculated human microvascular endothelial cells, HSPD1, MX1, STX1A, and GTPBP2 were the common upregulated OCRGs; and OPTN, BNIP3L, VAMP8, VPS41, AASS, EPS15, and PDCD6IP were the common downregulated OCRGs. When the overlapped three genes were removed, 59 genes are upregulated and 62 genes are downregulated in MERS coronavirus-inoculated cells. (C) Donut chart shows the ratio of classification of upregulated OCRGs (A) and downregulated OCRGs (B) in virus-treated cells. Classifications of upregulated OCRGs in icMERS- and influenza virus-inoculated cells are 15 and 12, respectively. Classifications of downregulated OCRGs in icMERS- and influenza virus-inoculated cells are 11 and 16, respectively.