Table 1.

Two hundred sixty organelle crosstalk regulators (OCRGs) were searched from three databases such as National Center for Biotechnology Information (NCBI), Gene Set Enrichment Analysis (GSEA), and the Human Protein Atlas (HPA) website.

Classification of OCRGs	No.	Gene symbol	Source
Mitochondrial biogenesis	5	POLG, VCP, HSPD1, HSPA4, LONP1	PMID: 28094012, 24784582, 22298039, 22424226, 21659532
Mitochondrial fission	28	COX10, DCN, DDHD1, DDHD2, DHODH, DNM1, DNM2, DNM3, GGNBP1, INF2, KDR, LRRK2, MAPT, MIEF1, MIEF2, MTFP1, MTFR1, MTFR1L, MTFR2, MX1, MX2, MYO19, PINK1, PPARGC1A, SLC25A46, STAT2, TMEM135, VPS35	Gene Set Enrichment Analysis (GSEA) (https://www.gsea-msigdb.org/gsea/index.jsp)
Mitochondrial fusion	15	ADCK1, AFG3L2, BAK1, BAX, CHCHD3, MFN1, MFN2, MIGA1, MIGA2, OMA1, PID1, PLD6, STOML2, USP30,VAT1	GSEA (https://www.gsea-msigdb.org/gsea/index.jsp)
Mitochondrial fission and fusion	7	BNIP3, DNM1L, FIS1, GDAP1, MFF, MUL1, OPA1	GSEA (https://www.gsea-msigdb.org/gsea/index.jsp)
Mitophagy	28	PINK1, OPTN, SQSTM1, PARL, USP30, RING1, RNF2, ATG9a, VMP1, CALCOCO2, ATG4a,ATG7, ATG3, ATG12, ATG5, ATG10, ATG13, OMA1, TBK1, GABARAP, MAP1LC3A, VDAC1, BNIP3L, BNIP3, FUNDC1, BCL2L13, FKBP8,	PMID: 27291334, 25479550, 29358684, 29370689, 30540226
Mitochondrial protein translocation	7	TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40, TOMM70	PMID: 28301740
Mitochondrial contact site	4	CHCHD3, CHCHD6, APOO, APOOL, IMMT	PMID: 24687277
Endoplasmic reticulum–mitochondria contact	13	RMDN3, VAPB, VAPA, BCAP31, MCU, ITPR1, HSPA9, BAK1, DAPK1, MFN1, MFN2, VDAC1, FIS1	PMID: 28301744, 26627931
Sarcoplasmic reticulum–mitochondria contact	9	VDAC1, HSPA9, ITPR1, SIGMAR1, ATP2A1, VAPB, RMDN3, OSBPL8, OSBPL5	PMID: 28275246
Endoplasmic reticulum–plasma membrane junctions	10	ORAI1, STIM1, SEC61B, JPH1, JPH2, JPH3, JPH4, PTPN1, STX1A, SEC22B	PMID: 26322679, 22914293, 28554772, 28301744
Endoplasmic reticulum–Golgi interaction	6	VAPA, VAPB, PLEKHA8, PITPNM1, OSBP, STX5	PMID: 32065234, 23913272, 24209621, 31357511
Endoplasmic reticulum–endosome	7	STARD3, PTPN1, EGFR, OSBPL1A, STARD3NL, RAB7A, NPC1	PMID: 26627931
Autophagosome–lysosome fusion	4	OCRL, MCOLN1, TLR9, TIRAP	PMID: 27398910
Autophagosome–endosome/lysosome fusion	9	VAMP8, RAB7A, PLEKHM1, RILP, ATG14, VPS39, VPS41, SNAP29, STX17	PMID: 27283760
Endosome–Golgi trafficking	4	TBC1D23, GOLGA1, GOLGA4, FAM91A1	PMID: 29084197
Vesicle	125	AASS, ABCD3, ABHD14A, ACAA1, ACBD5, ADCYAP1R1, AGPS, AKAP9, ANKFY1, ANKRD2, ANKRD6, AP1B1, AP1G1, ARCN1, ATP11A, ATP23, AZU1, BMP2, C7orf43, CAT, CCDC93, CCZ1, CCZ1B, CD24, CDKL1, CHGB, CHIC2, CLIP4, CLOCK, CLTA, CLTC, CNNM2, CSF2, CSTF2T, CTAG2, CTSA, CYB5A, CYP27C1, DAB1, DAB, DBH, DNAJA3, DPP7, DRAM2, DYRK4, ECI2, EDA, EIF4ENIF1, EPS15, ERGIC1, FAF2, FYCO1, GPRC5A, GRN, GTPBP2, HDHD3, HEXIM1, HGS, HIP1, HSD17B4, HSD3B7, IGF2R, ITCH, ITM2B, KLRG1, LAMP3, MBD1, MEF2D, MIA3, MITD1, NACC1, NMRK2, NOV, NSDHL, OSBPL5, P4HA2, PDCD6IP, PDXDC1, PEX14, PICALM, PLCH1, PLIN3, PLIN4, PNPLA2, POU2F2, PPARG, PPOX, PUSL1, RAB11A, RAB11FIP1, RAB11FIP5, RAB20, RAB30, RAB5C, RALY, RANBP2, RANGAP1, RC3H2, RPS6KC1, RPTOR, RUNX1, SAMD9, SEC23IP, SERPINA1, SERTM1, SET, SNX1, SPINK5, SQSTM1, STK11IP, STX16, SYNDIG1, SYNPO2, TBK1, TMEM63A, TNPO3, TYR, VAC14, VPS26A, VTI1B, ZDHHC13, ZFYVE16, ZFYVE9, ZNF266, ZNF326	The human protein atlas (HPA) (https://www.proteinatlas.org/humanproteome/cell/vesicles)