Table 11.
Nineteen microarrays of deficiencies of oncogene and tumor suppressor in the National Institutes of Health (NIH)–National Center for Biotechnology Information (NCBI)–Gene Expression Omnibus (GEO) datasets database (https://www.ncbi.nlm.nih.gov/gds/) were collected to analyze the expression changes of organelle crosstalk regulators (OCRGs) (p < 0.05, |logFC| > 1).
| GEO ID | Comparison | Organism | Cells/tissue | Upregulated | Downregulated | PMID |
|---|---|---|---|---|---|---|
| GSE30049 | IKK2 knockout vs. wild type | Mus musculus | Lung tumor cell lines | 5 | 5 | 22327365 |
| IKK2 knockout vs. wild type | M. musculus | Lung tumor nodules | 1 | 0 | 22327365 | |
| GSE46250 | IKK complex inhibition vs. control | M. musculus | Leukemia cells | 1 | 0 | 24054986 |
| GSE46251 | IKK complex inhibition vs. control | Homo sapiens | Leukemia cells | 0 | 1 | 24054986 |
| GSE71444 | IKK2 knockdown vs. scramble control | H. sapiens | Human MDA-MD-231 cells | 0 | 0 | 29662632 |
| RELA knockdown vs. scramble control | H. sapiens | Human MDA-MD-231 cells | 1 | 2 | 29662632 | |
| GSE36568 | Rela knockout vs. wild type | M. musculus | Lung carcinoma cells | 5 | 2 | NA |
| GSE54645 | JAK2 knockdown vs. control | H. sapiens | AML cell line | 0 | 1 | 24740812 |
| GSE44652 | STAT1 knockdown vs. control | H. sapiens | Human T-All cell line | 1 | 5 | 23471820 |
| GSE75325 | Stat3 knockout vs. wild type | M. musculus | Mouse mammary tumors | 2 | 1 | 26719528 |
| GSE48124 | STAT3 knockdown vs. control | H. sapiens | Urothelial cancer cell line | 0 | 1 | 24525232 |
| GSE34760 | Tp53 knockout vs. wild type | M. musculus | Liver tumors | 23 | 48 | 22342966 |
| Tp53 knockout vs. wild type | M. musculus | Liver | 6 | 13 | 22342966 | |
| GSE40545 | Tp53, Rb double knockout vs. wild type | M. musculus | Mammary epithelial cells | 7 | 1 | 25602521 |
| Tp53 knockout vs. wild type | M. musculus | Mammary epithelial cells | 15 | 4 | 25602521 | |
| GSE62694 | Mutant Tp53 vs. control | M. musculus | Oviductal cells | 4 | 1 | 25810107 |
| GSE76296 | Mutant Tp53 vs. wild type | M. musculus | Neural stem cells | 0 | 1 | 26984279 |
| GSE70262 | Tp53 knockout vs. wild type | M. musculus | Small intestine | 0 | 0 | 18533991 |
| APC knockout vs. wild type | M. musculus | Small intestine | 6 | 3 | 18533991 | |
| GSE39955 | Tp53 knockout vs. control | M. musculus | Neu primary tumor | 6 | 4 | 25330770 |
| PTEN knockout vs. control | M. musculus | Neu primary tumor | 7 | 4 | 25330770 | |
| GSE54265 | PTEN knockdown vs. control | H. sapiens | Breast cells lines | 5 | 1 | 24553445 |
| GSE68869 | PTEN knockdown vs. control | H. sapiens | Lung adenocarcinoma cells | 1 | 0 | 25995385 |
| GSE120478 | PTEN null vs. wild type | M. musculus | Mouse embryonic fibroblasts | 1 | 0 | 31169889 |
| GSE121217 | PTEN knockdown vs. control | H. sapiens | Lung adenocarcinoma cells | 0 | 2 | 31461649 |