Table 3.
Three microarray datasets of time course including MERS coronavirus, SARS coronavirus, avian influenza virus, one dataset of influenza virus infected human umbilical vein endothelial cells and one dataset of Kaposi sarcoma-associated herpes virus infection in the National Institutes of Health (NIH)–National Center for Biotechnology Information (NCBI)–Gene Expression Omnibus (GEO) datasets database (https://www.ncbi.nlm.nih.gov/gds/) were collected to analyze the expression changes of genes that we are interested in.
| GEO ID | Comparison | Cell/tissue | Upregulated | Downregulated | PMID |
|---|---|---|---|---|---|
| GSE79218 | icMERS-inoculated vs. mock-inoculated (0 h) | Human microvascular endothelial cells | 0 | 1 | 28830941 |
| icMERS-inoculated vs. mock-inoculated (12 h) | Human microvascular endothelial cells | 20 | 16 | 28830941 | |
| icMERS-inoculated vs. mock-inoculated (24 h) | Human microvascular endothelial cells | 41 | 44 | 28830941 | |
| icMERS-inoculated vs. mock-inoculated (36 h) | Human microvascular endothelial cells | 39 | 46 | 28830941 | |
| icMERS-inoculated vs. mock-inoculated (48 h) | Human microvascular endothelial cells | 25 | 24 | 28830941 | |
| GSE47960 | SARS-CoV-infected vs. mock-infected (0 h) | Human airway epithelium cells | 3 | 0 | 23935999 |
| SARS-CoV-infected vs. mock-infected (12 h) | Human airway epithelium cells | 0 | 0 | 23935999 | |
| SARS-CoV-infected vs. mock-infected (24 h) | Human airway epithelium cells | 2 | 1 | 23935999 | |
| SARS-CoV-infected vs. mock-infected (36 h) | Human airway epithelium cells | 1 | 0 | 23935999 | |
| SARS-CoV-infected vs. mock-infected (48 h) | Human airway epithelium cells | 3 | 0 | 23935999 | |
| SARS-CoV-infected vs. mock-infected (60 h) | Human airway epithelium cells | 15 | 0 | 23935999 | |
| SARS-CoV-infected vs. mock-infected (72 h) | Human airway epithelium cells | 4 | 2 | 23935999 | |
| SARS-CoV-infected vs. mock-infected (84 h) | Human airway epithelium cells | 5 | 0 | 23935999 | |
| SARS-CoV-infected vs. mock-infected (96 h) | Human airway epithelium cells | 7 | 1 | 23935999 | |
| H1N1-infected vs. mock-infected (0 h) | Human airway epithelium cells | 1 | 0 | 23935999 | |
| H1N1-infected vs. mock-infected (6 h) | Human airway epithelium cells | 6 | 0 | 23935999 | |
| H1N1-infected vs. mock-infected (12 h) | Human airway epithelium cells | 11 | 6 | 23935999 | |
| H1N1-infected vs. mock-infected (18 h) | Human airway epithelium cells | 20 | 21 | 23935999 | |
| H1N1-infected vs. mock-infected (24 h) | Human airway epithelium cells | 22 | 29 | 23935999 | |
| H1N1-infected vs. mock-infected (36 h) | Human airway epithelium cells | 27 | 30 | 23935999 | |
| H1N1-infected vs. mock-infected (48 h) | Human airway epithelium cells | 18 | 16 | 23935999 | |
| GSE49840 | H7N9-infected vs. mock-infected (3 h) | Calu-3 cells | 1 | 2 | 24496798 |
| H7N9-infected vs. mock-infected (7 h) | Calu-3 cells | 3 | 0 | 24496798 | |
| H7N9-infected vs. mock-infected (12 h) | Calu-3 cells | 8 | 3 | 24496798 | |
| H7N9-infected vs. mock-infected (24 h) | Calu-3 cells | 30 | 70 | 24496798 | |
| H7N7-infected vs. mock-infected (3 h) | Calu-3 cells | 1 | 0 | 24496798 | |
| H7N7-infected vs. mock-infected (7 h) | Calu-3 cells | 0 | 0 | 24496798 | |
| H7N7-infected vs. mock-infected (12 h) | Calu-3 cells | 5 | 4 | 24496798 | |
| H7N7-infected vs. mock-infected (24 h) | Calu-3 cells | 38 | 109 | 24496798 | |
| H5N1-infected vs. mock-infected (3 h) | Calu-3 cells | 1 | 2 | 24496798 | |
| H5N1-infected vs. mock-infected (7 h) | Calu-3 cells | 2 | 0 | 24496798 | |
| H5N1-infected vs. mock-infected (12 h) | Calu-3 cells | 6 | 0 | 24496798 | |
| H5N1-infected vs. mock-infected (24 h) | Calu-3 cells | 40 | 92 | 24496798 | |
| H3N2-infected vs. mock-infected (3 h) | Calu-3 cells | 1 | 3 | 24496798 | |
| H3N2-infected vs. mock-infected (7 h) | Calu-3 cells | 3 | 0 | 24496798 | |
| H3N2-infected vs. mock-infected (12 h) | Calu-3 cells | 12 | 16 | 24496798 | |
| H3N2-infected vs. mock-infected (24 h) | Calu-3 cells | 19 | 42 | 24496798 | |
| GSE59226 | Influenza virus (H9N2)-infected vs. inactivate virus-infected | Human umbilical vein endothelial cells | 27 | 137 | 25863179 |
| GSE1377 | Kaposi sarcoma-associated herpes virus-infected for 7 days vs. uninfected control | Primary human dermal endothelial cells | 6 | 10 | 15220917 |
MERS-CoV, Middle East respiratory syndrome coronavirus; SARS-CoV, severe acute respiratory syndrome coronavirus; H1N1, H7N9, H7N7, H5N1, H3N2, and H9N2, influenza viruses.