Table 6.
Fifteen microarrays of regulatory T cell regulator deficiency in the National Institutes of Health (NIH)–National Center for Biotechnology Information (NCBI)–Gene Expression Omnibus (GEO) datasets database (https://www.ncbi.nlm.nih.gov/gds/) were collected to analyze the expression changes of OCRGs (p < 0.05, |logFC| > 1).
| GEO ID | Comparison | Source | Cell | Upregulated | Downregulated | PMID |
|---|---|---|---|---|---|---|
| GSE39864 | Gata3 knockout vs. wild type | Spleen and LN | CD4+CD25+ Treg | 0 | 0 | 22922362 |
| GSE40493 | Bcl6 knockout vs. wild type | Spleen and LN | FoxP3+ Treg | 7 | 0 | 23053511 |
| GSE27896 | Hdac6 knockout vs. wild type | Lymphoid tissues | CD4+CD25+ Treg | 1 | 0 | 21444725 |
| GSE36095 | Hdac9 knockout vs. wild type | Spleen and LN | CD4+CD25+ Treg | 0 | 0 | 22715468 |
| GSE11818 | Dicer knockout vs. wild type/heterozygote | LN | CD4+ T cells | 5 | 1 | 18725525 |
| GSE14350 | IL-2R defective vs. normal | Spleen | CD4+CD25+ Treg | 1 | 3 | 19185518 |
| GSE27143 | Blimp1 gfp/gfp vs. +/gfp | Bone marrow | CD4+CD25+ Treg | 3 | 6 | 21378976 |
| GSE37532 | Pparg– vs. Pparg+ | LN | CD4+ T cells | 0 | 0 | 22722857, 25550516 |
| Pparg– vs. Pparg+ | VAT | CD4+ T cells | 1 | 3 | 22722857, 25550516 | |
| GSE40273 | Eos knockout vs. wild type | Spleen | CD4+CD25hi Treg | 0 | 0 | 22961053 |
| GSE40657 | Foxo1 knockout vs. wild type | thymus, Spleen and LN | CD4+ T cells | 6 | 1 | 23135404 |
| GSE47989 | Ep300–/– vs. wild type | Spleen | CD4+CD25+ Treg | 0 | 1 | 23955711 |
| GSE60318 | deletion of p300 vs. wild type | Spleen and LN | CD4+CD25+ Treg | 0 | 1 | 25154413 |
| GSE18148 | Cbfb-deficient vs. control | Peripheral CD4+CD25hi cells | FoxP3+ Treg | 2 | 0 | 19800266 |
| GSE32224 | Trim28 knockout vs. wild type | Spleen and LN | CD4+CD62+CD25+ Treg | 3 | 5 | 22544392 |
| GSE61077 | TCR knockout vs. wild type | spleen and LN | CD44 high Treg | 1 | 1 | 25263123 |
KO, knockout; WT, wild type; LN, lymph node; VAT, visceral adipose tissue.