Table 7.
Six microarrays of toll-like receptor deficiencies in the National Institutes of Health (NIH)–National Center for Biotechnology Information (NCBI)–Gene Expression Omnibus (GEO) datasets database (https://www.ncbi.nlm.nih.gov/gds/) were collected to analyze the expression changes of organelle crosstalk regulators (OCRGs) (p < 0.05, |logFC| > 1).
| GEO ID | Comparison | Cell/tissue | Upregulated | Downregulated | PMID |
|---|---|---|---|---|---|
| GSE24935 | Tlr2 KO+infection of SA vs. WT+infection of SA (6 h) | Glial | 6 | 0 | 21901759 |
| Tlr2 KO+infection of SA vs. WT+infection of SA (12 h) | Glial | 2 | 14 | 21901759 | |
| GSE56426 | Tlr2 KO+injection of MTX vs. WT+injection of MTX | Proximal jejunum | 24 | 23 | 25589072 |
| GSE45861 | Tlr2 KO+infection of European strain (P1/7) of Streptococcus suis vs. WT+infection of European strain (P1/7) of S. suis | Spleen | 5 | 1 | 23724118 |
| Tlr2 KO+infection of Chinese strain (SC84) of S. suis vs. WT+infection of Chinese strain (SC84) of S. suis | Spleen | 4 | 6 | 23724118 | |
| GSE31066 | Tlr4 KO+LPS treatment vs. WT+LPS treatment | Macrophage | 4 | 10 | 21865549 |
| Tlr4 KO+lipid A treatment vs. WT+lipid A treatment | Macrophage | 4 | 10 | 21865549 | |
| GSE103750 | Tlr7 KO+infection of STM vs. WT+infection of STM | Macrophage | 1 | 1 | 29616197 |
| GSE92358 | Tlr3/7/9 KO+injection with MOPC cells vs. WT+injection with MOPC cells (day 4) | Tumor tissues | 5 | 7 | 28300057 |
| Tlr3/7/9 KO+injection with MOPC cells vs. WT+injection with MOPC cells (day 6) | Tumor tissues | 7 | 8 | 28300057 |
KO, knockout; WT, wild type; SA, Staphylococcus aureus; MTX, methotrexate; STM, Salmonella enterica serovar Typhimurium; MOPC, murine oropharyngeal carcinoma cell.