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. 2021 Jul 22;12:641308. doi: 10.3389/fphar.2021.641308

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Copyright © 2021 Fu, Jiang, Guo, Liao, Liu and Xiong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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rhKGF-2 eased the inflammation and oxidative stress in the SILI rat model. The SILI rat model was established by inhalation of smoke. Then, rhKGF-2 (10 ng/kg body weight), GSK2126458 (300 μg/kg body weight) and AS1842856 (10 μg/kg body weight) were used for were used for treating the SILI rats, the same volume of saline was administered on the rat in the sham group. A–F: The release of pro-inflammatory cytokines TNF-α (A), IL-1β (B), hs-CRP (C), and the levels of oxidative stress markers MDA (D), SOD (E), and GSH-PX. (F) in the lung of rats were determined by ELISA. The Y-axis shows the content of the detected mediators. The X-axis shows the grouping name. Data are expressed as mean ± SD. All experiments were repeated for three times. Data difference was analyzed via ANOVA, and Student’s t test. NSP>0.05, *p<0.05, **p<0.01, ***p<0.001. Five rats were involved in each group (N = 5).