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The mechanism diagram. rhKGF2 enhanced the activation of PI3K/AKT pathway, inhibited the phosphorylation of FoxO1, thus repressing NLRP3-ASC-Caspase1 inflammasome and promoted Nrf2/HO-1/NQO1 axis. Finally, rhKGF2 repressed inflammation and oxidative stress of alveolar epithelial cells.
