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Immune response in cancer. CD8+ T cells are activated and become CTLs upon recognition of cancer antigens presented by MHC class I on dendritic cells. CTLs recognize cancer antigens on the surface of cancer cells through T cell receptors and attack the cancer. TCR, T cell receptor; MHC, major histocompatibility complex; TAA, tumor-associated antigen; DC, dendritic cell. Modified from Abbas et al. [20].
