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. 2021 Aug 5;142:112011. doi: 10.1016/j.biopha.2021.112011

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 4 — Effect of glycyrrhiza uralensis Fisch. ex DC. extract (GU), theaflavin (Tf) and (+)-catechin (Cate) on interaction between ACE2 and SARS-CoV-2 Spike. (A, C, G) The indicated compounds were tested to evaluate their ability to inhibit the binding of spike protein to immobilized ACE2 by the ACE2/SARS-CoV-2 spike inhibitor screening assay. (B) The structure of (+)-catechin. (D) The structure of theaflavin. (E, F) HPLC chromatograms of theaflavin.