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. 2021 Jul 22;9:689624. doi: 10.3389/fcell.2021.689624

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Copyright © 2021 Rotondo, Lanzillotti, Mazziotta, Tognon and Martini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigenetic reprogramming during gametogenesis. Changes of DNA methylation occur during primordial germ cell (PGC) development. During the proliferation and migration into the gonadal ridge, PGCs undergo global demethylation to remove parental imprints. Subsequently, reestablishment of the male germ cell DNA methylation patterns occurs during gametogenesis. De novo methylation occurs prior to meiosis in mitotically arrested cells while being completed before birth.