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Ligation of TIGIT on Tregs contributes to dampening of anti-tumor immunity. (A) Ligation of TIGIT augments suppressive function of Tregs, which inhibits Th1/17 cell, CD8+ T cell or NK responses via production of Fgl2 and IL-10. On the contrary, PD-1 ligation may reduce Treg suppressive function. (B) Single blockade of PD-1 may enhance Treg immunosuppression, whereas dual blockade of TIGIT and PD-1 may counteract this resistance mechanism.
