Table 3.
Regression coefficients and 95% confidence intervals of multiple linear regression models of association between characteristics of acute respiratory illness and IgG concentrations or neutralizing antibody titer in seropositive individuals, adjusted for age, sex or time since onset of symptoms or multiply imputed positive PCR test.
| Anti-RBD IgG by LIPS | Anti-N IgG by LIPS | Anti-N IgG by Abbott | Neutralizing antibodies by neutralization assay | |
|---|---|---|---|---|
| Acute respiratory illness | 29.0 (−19.0…77.0) | 5.0 (−0.1…10.1) | 1.5 (−0.1…3.0) | 0.6 (−0.7…1.9) |
| Fever ≥ 38 °C | 62.4 (0.6…124.2)a | 9.8 (3.4…16.3)b | 3.0 (1.1…4.9)b | 1.2 (−0.5…2.9) |
| Chills | −10.5 (−73.8…52.8) | 1.6 (−5.2…8.4) | 0.4 (−1.6…2.5) | 0.01 (−1.7…1.7) |
| Fatigue | 14.2 (−37.0…65.5) | 4.5 (−0.9…10.0) | 1.1 (−0.6…2.7) | 0.3 (−1.0…1.7) |
| Muscle aches | 23.3 (−37.0…83.5) | 4.2 (−2.3…10.7) | 1.3 (−0.6…3.2) | 0.5 (−1.1…2.2) |
| Sore throat | −50.1 (118.9…18.7) | −2.9 (−10.4…4.6) | 0.3 (−2.0…2.5) | −0.5 (−2.4…1.3) |
| Cough | 20.9 (−45.3…87.1) | 5.6 (−1.5…12.6) | 1.7 (−0.4…3.8) | 0.6 (−1.2…4.1) |
| Runny nose | 12.3 (−46.4…71.0) | 3.8 (−2.5…10.0) | 1.5 (−0.3…3.4) | 1.0 (−0.5…2.6) |
| Difficulty breathing | 69.7 (−4.1…143.5) | 9.3 (1.4…17.1)a | 2.3 (−0.1…4.6) | 1.0 (−1.0…3.1) |
| Shortness of breath | 53.6 (−25.8…132.9) | 9.4 (1.1…17.8)a | 2.6 (0.1…5.1)a | 1.7 (−0.4…3.9) |
| Chest pain | 46.0 (−31.2…123.3) | 8.1 (−0.1…16.4) | 3.2 (0.9…5.6)b | 1.0 (−1.1…3.1) |
| Other respiratory symptoms | −8.9 (−116.2…98.4) | 2.7 (−8.8…14.3) | 1.5 (−1.9…5.0) | −0.1 (−3.0…2.8) |
| Headache | 4.1 (−49.2…57.4) | 1.9 (−3.8…7.6) | 0.5 (−1.2…2.2) | 0.1 (−1.3…1.6) |
| Stomach ache | −60.2 (−165.4…45.0) | −7.6 (−18.9…3.7) | −1.0 (−4.4…2.4) | −2.0 (−4.8…0.9) |
| Diarrhea | 31.1 (−38.2…100.4) | 6.4 (−1.0…13.7) | 2.5 (0.4…4.7)a | 0.3 (−1.6…2.2) |
| Hospitalized | 102.8 (13.6…192.0)a | 10.5 (0.9…20.2)a | 2.7 (−0.2…5.6) | 1.3 (−1.2…3.8) |
Statistically significant regression coefficients are shown in bold.
a
p-value between 0.01 and 0.05, bp-value < 0.01.