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. 2021 Jul 22;12:668219. doi: 10.3389/fimmu.2021.668219

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Copyright © 2021 Hetemäki, Jian, Laakso, Mäkitie, Pajari, de Vos, Arstila and Salonen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Principal coordinate analysis (PCoA) based on Bray–Curtis distances using the predicted functional modules showing differences in the gut microbiota compositions between patients with APECED (black) and healthy controls (red). (B) Predicted functional modules significantly overrepresented in patients with APECED (black) and controls (red). (C) Receiver operating characteristic (ROC) curves of the cross-validated random forest models constructed using the imputed functions (red) and relative abundances of genera (green).