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. 2021 Jul 22;12:714943. doi: 10.3389/fimmu.2021.714943

Figure 1.

Figure 1

Rux reduced infarct size, neurological deficits and cerebral edema in mice after MCAO. (A) Representative TTC-stained slices showing infarction in vehicle- and Rux-treated mice. (B) Quantitative analysis of the infarct size is presented as a percentage of the contralateral hemisphere size 3 days after stroke. (C) Neurological scores were determined 3 days after MCAO. (D) Representative western blots showing that Rux application reduced AQP4 expression. (E) Quantification of AQP4 expression. (F) Quantification of water content. Means ± SD. n = 5 in each group. aP < 0.05 versus the vehicle group; bP < 0.05 versus the 30 mg/kg Rux group; cP < 0.05 versus the 60 mg/kg Rux group.