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Rux treatment decreased the number of NLRP3+ and CD68+ cells in the ischemic penumbra. (A) Representative images of NLRP3 and CD68 immunostaining in the ischemic penumbra of sham-, vehicle-, Rux- and MCC950-treated mice 3 days after stroke. (B, C) Statistical analysis of NLRP3+ and CD68+ cells. (D) Quantification of double-positive cells in the peri-ischemic region. Means ± SD. n = 5. aP < 0.01 versus sham; bP < 0.01 versus vehicle. Scale bar: 50 µm.
