Table 3.
Genetic susceptibility to infections in mice.
| Infections | Genetic variation | Effect of genetic variation | References |
|---|---|---|---|
| Influenza A virus | chromosome Y | ↗ susceptibility to infection of males | (96) |
| ↗ pathogenic immune responses in lungs | |||
| Coxsackievirus B3 | chromosome Y | ↗ mortality in infected males | (97) |
| Resistance genes | Effect of resistance genes | ||
| P. chabaudi | Char 1-4 | greater resistance of females (Char 2, Char 4) | (98) |
| L. mexicana | Scl-2 | greater resistance of females | (99) |
| Mousepox | Rmp1–4 | greater resistance of females (Rmp 2, Rmp 4) | (100) |
Genetic variations in the Y chromosome influence the survival of male mice following influenza A virus and coxsackievirus B3 infection. Resistance genes have been identified, and the effects of these genes confer greater resistance to infections for female mice.