Table 1. Clusters with significant age-related susceptibility increase identified by whole brain analysis with corresponding anatomical locations.

Cluster volume [mm3]	Peak susceptibility change [ppb/year]	Peak T value	MNI coordinates [mm]			Peak structure	Anatomical structures within cluster
			X	Y	Z
10,477	1.7	10.7	16	1	−5	Putamen*	Right putamen, pallidum, caudate, substantia nigra, red nucelus*
10,018	1.5	10.3	−14	1	−4	Putamen*	Left putamen, pallidum, caudate, sub-stantia nigra, red nucleus*
464	0.8	5.1	−15	−60	−37	Dentate*	Left dentate*
369	0.7	4.9	15	−58	−37	Dentate*	Right dentate*
3,126	0.5	7.0	−41	−11	56	Precentral gyrus	Left precentral gyrus, paracentral lob-ule
685	0.5	4.9	−23	−68	7	Calcarine gyrus	Left calcarine, lingual, fusiform gyri, parietooccipital sulcus
914	0.4	4.8	−41	−21	4	Superior temporal gyrus	Left superior temporal gyrus, posterior insula
3,628	0.4	6.4	23	−22	63	Precentral gyrus	Right precentral gyrus, paracentral lobule
811	0.4	4.8	45	−16	0	Superior temporal gyrus	Right superior temporal, supramargin-al gyri, posterior insula
1,902	0.4	5.0	−8	−35	47	Cingulate sulcus	Left cingulate sulcus, superior frontal gyrus, paracentral lobule
252	0.3	6.4	29	−54	−16	Fusiform gyrus	Right fusiform, lateral occipital gyri
303	0.3	4.7	5	−88	30	Superior occipital gyrus	Right superior occipital, calcarine gyri, cuneus
3,779	0.3	6.3	4	−26	66	Paracentral lobule	Right paracentral lobule, cingulate sulcus, superior frontal gyri
210	0.3	4.7	−25	−76	28	Middle occipital gyrus	Left middle occipital, angular gyri, in-traoccipital sulcus
442	0.3	3.8	13	−30	0	Thalamic pulvinar*	Right thalamus*
485	0.3	5.3	2	−55	−36	Cerebellum	Cerebellar vermis
1,503	0.3	5.4	23	11	63	Superior frontal sulcus	Right superior frontal gyrus and sul-cus, precentral sulcus
193	0.3	4.9	−4	−81	26	Cuneus	Left cuneus, calcarine, superior occip-ital gyri
383	0.3	4.1	35	11	25	Inferior frontal gyrus	Right inferior frontal gyrus, precentral sulcus
326	0.3	4.9	−2	−74	34	Parietooccipital sulcus	Left parietooccipital sulcus, precuneus
635	0.2	4.6	45	−25	43	Postcentral sulcus	Right postcentral sulcus and gyrus
1,241	0.2	4.7	−33	−4	54	Superior frontal gyrus	Left superior frontal sulcus and gyrus, precentral sulcus
427	0.2	4.2	26	−73	29	Middle occipital gyrus	Right middle occipital, angular gyri, intraoccipital, intraparietal sulci
239	0.2	3.9	−50	−47	32	Supramarginal gyrus	Left supramarginal, inferior parietal gyri
373	0.2	4.1	−6	−66	−58	Cerebellum	Left and right cerebellar tonsils

*Deep gray matter structures.