FIGURE 1.

Flow‐chart detailing the study design. AAA, Age at assessment; ADGC, Alzheimer's Disease Genetics Consortium; AIBL, The Australian Imaging, Biomarkers & Lifestyle Flagship Study of Ageing; AOO, age of onset; ASPREE, Aspirin in Reducing Events in the Elderly study; IGAP, International Genomics of Alzheimer's Project; OR, odds ratio; PC, principal components; PRS, polygenic risk score; QC, quality control. Summary statistics for IGAP stage 1 and 2 samples derived from Lambert et al. ¹⁶ Principal component analysis (PCA) was done using first ten PCs based on the 1000 Genomes reference population