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. 2021 Jul 22;11:699889. doi: 10.3389/fonc.2021.699889

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Copyright © 2021 Cui, Qiao, Jiang, Hu, Wang, Liu, Qin, Wang, Zheng, Zhang, Ma, Chen and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTK7 promotes in vivo TNBC tumorigenicity. (A) Nude mice were injected into the mammary fat pad with shNC-, shPTK7#1- or shPTK7#2-transduced MDA-MB-468 cells at 5×10⁵ cells per site. Mice were sacrificed and tumors were photographed 61 days after subcutaneous injection. (B) Tumor volume was monitored every 2 days after injection and tumor growth curve is shown. Tumor volume was calculated by the formula: V = 1/2×a (length)×b ² (width). (C) The harvest tumor weight was shown as mean ± s.d. ***P < 0.001; ****P < 0.0001.