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. 2021 Jul 22;12:688946. doi: 10.3389/fphys.2021.688946

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Copyright © 2021 Sahanic, Löffler-Ragg, Tymoszuk, Hilbe, Demetz, Masanetz, Theurl, Holfeld, Gollmann-Tepeköylü, Tzankov, Weiss, Giera and Tancevski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mediator lipidome in influenza and SARS-CoV-2 infection. (A) The graph summarizes common 6-PUFA- and 3-PUFA-derived bioactive and pro-resolving lipid mediators (AA, arachidonic acid; DHA, docosahexaenoic acid; and EPA, eicosapentaenoic acid). While severe influenza infection showed inhibition of protectin D1 (PD1) synthesis, severe SARS-CoV-2 infection was associated with a significant reduction in E-series resolvin 3 (RvE3). (B) Lipid mediator grouping according to synthetic pathways. (C) Transcriptional regulation of key enzymes involved in lipid mediator synthesis in PBMCs and BALF cells from patients affected by COVID-19.