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. 2021 Jul;9(13):1089. doi: 10.21037/atm-21-539

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Natural killer (NK)-based adoptive transfer immunotherapy (ATI) outcome in a rat model of hepatocellular carcinoma (HCC). (A) The tumor volume changes after 8 days of NK cell infusion. (B,C,D) Representative CD56-stained histology slices corresponding to subjects from the control group with transcatheter intra-hepatic arterial (IHA) saline (B), intravenous (IV) NK cell (C), and transcatheter IHA NK cell infusion after 8 days of infusion (D). (E) The IHA NK cell infusion group had a significantly (P<0.0001) improved number of CD56⁺ NKs compared to the control group. (B,C,D) Scale bars =100 µm. [Adapted from Su et al. (46), Copyright 2018 by John Wiley & Sons Ltd.]