Table 2. The list of clinical trials registered to United States National Library of Medicine (www.clinicaltrials.gov) for treatment of HCC patients using IRE.
Study title | Phase | Intervention/treatment | Patient | Status | Results | Identifier |
---|---|---|---|---|---|---|
A prospective, multi-center, clinical trial using IRE for the treatment of early-stage HCC | NA | Dev.: NanoKnife Low Energy Direct Current (LEDC) System | 26 | C | 77% CR presented on 1 month biopsy-proven results | NCT01078415 |
A prospective clinical trial using IRE for the treatment of unresectable hepatic carcinoma (HC) close to the gallbladder | NA | Dev.: NanoKnife | 30 | R | No results posted | NCT02332551 |
HC in poor liver function: safety and efficacy of IRE | NA | Dev.: NanoKnife LEDC System | 15 | R | Frequent hypertension due to adrenal gland damage | NCT02352935 |
Comparison of immunological response after MWA and IRE of HCC | NA | Device: MWA, NanoKnife IRE | 40 | W | No results posted | NCT03040453 |
A prospective clinical trial using IRE for treatment of liver cancers | NA | Dev.: IRE System | 18 | C | No results posted | NCT02828865 |
Study of the contribution of automatic image fusion of a cone-beam CT volume with ultrasound during percutaneous ablation treatment of hepatic tumors | NA | Rad.: interact active tracker | 60 | R | No results posted | NCT04420026 |
IRE of unresectable liver tumors - a phase I study of safety and feasibility | NA | Proc.: IRE | 15 | R | No results posted | NCT04404647 |
Prospective evaluation of tumor response to cancer treatment therapies | – | Proc.: TACE, Y-90, MWA, IRE | 10 | T | No results posted | NCT02787954 |
Evaluation of tumor ablation effects by IRE for patients with malignant liver tumors | NA | Proc.: IRE | 20 | C | No results posted | NCT02010801 |
A, active; C, completed; R, recruiting; T, terminated; W, withdrawn; HCC, hepatocellular carcinoma; IRE, irreversible electroporation; MWA, microwave ablation; NA, not available; TACE, transarterial chemoembolization.